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Title Microencapsulation of a-Tocopherol Using Hydroxypropyl Cellulose-Blended Sodium Alginate
Posted by Rodel Guerrero
Authors Guerrero, Rodel D.; Casalme, Lara Angelica R.; Nalzaro, Paul Jake B.; Osabel, Raymund Joseph N.; Pescos, Charisse Joy H.; Tumolva, Terence P.
Publication date 2016/12
Conference 2016 International Conference on Materials and Chemical Engineering
Abstract Vitamin E is a micronutrient essential to human health with one of its isoforms, α-tocopherol, functioning as a chain-breaking antioxidant. However, it is only partially absorbed at the intestinal site where vitamins should be transported, thereby reducing its bioavailability. In order to protect an encapsulated drug from degradation, microencapsulation can be applied. Hence, it is this study’s aim to synthesize and characterize microencapsulated α-tocopherol. The microcapsules were synthesized with the use of different mixtures of sodium alginate and hydroxypropyl cellulose as the coating material, and calcium chloride as the hardening agent. SEM images show that 25:75 alginate-HPC ratio is incapable of encapsulating the drug while the 100:0, 75:25, and 50:50 ratios are capable, as supported by FTIR results. Morphological analysis show that microcapsules are larger and more spherical with increasing alginate content. It was also found out that at 54.75%, the 50:50 blending ratio is the most efficient in encapsulating the drug. Lastly, the swelling test shows that the microcapsules would be able to traverse the acidic environment of the stomach (pH = 1.2), targeting the intestines (pH = 7.4) for the intended drug release where the microcapsules disintegrate.
Index terms / Keywords a-tocopherol, sodium alginate, hydroxypropyl cellulose, microencapsulation