Conference
| Title | ALPHA-GLUCOSIDASE AND 15-LOX INHIBITION ACTIVITIES OF SOME FRUIT AND VEGETABLE PEELS Posted by Chona Gelani |
| Authors | Chona Gelani, Marie Rose Baghocan, Godzelle Bulahan, Empress Diadem Honcada, Stephen Ladera, Daniella Shane Saure, Mitz Tapi-on, and Renzo Luis Reazo |
| Conference | 31st International Symposium on the Chemistry of Natural Products and 11th International Congress on Biodiversity |
| Abstract | Solid vegetable and fruit wastes such as peels, pomace and pulp are generated during the production and manufacturing processes [1] and they end up in the dump site. This study is an attempt of waste utilization in a way that if found to exhibit pharmacologic properties, these fruit and vegetable peels will be put into good use and will no longer be considered waste by-products. Methanol and hexane crude extracts of the peels of banana blossom (Musa balbisiana, Mb), red beetroot (Beta vulgaris, Bv), sponge gourd (Luffa cylindrica, Lc), miracle fruit (Crescentia cujete, Cc), and yellow passion fruit (Passiflora edulis, Pe) were evaluated for their antidiabetic and anti-inflammatory properties using α-glucosidase[2] and 15-LOX inhibition[3] assays. At 200 ppm, the hexane extract of Bv, Cc, and Pe inhibited α-glucosidase at 98.28, 98.24, and 96.95%, respectively. These results are at par with that of acarbose (98.32%) at the same concentration. The methanolic extract of Bv and Cc gave an inhibition activity of 42.87 and 36.10%, respectively. At 100 ppm, methanol extract of Pe inhibited 15-LOX with 43.14% inhibition followed by the methanol extract of Lc at 36.63%. The study has shown that the hexane extracts of Bv, Cc, and Pe have antidiabetic potentials. Further confirmatory assays are recommended to corroborate these results. On the other hand, compared to nordihydroguaretic acid (NDGA), a moderate to weak anti-inflammatory activity, were shown by Pe and Lc. Other anti-inflammatory tests are recommended. |
| Index terms / Keywords | Alpha-glucosidase, 15-LOX, fruit peels, antioxidant, anti-inflammatory |